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Development of a O-Conotoxin Analogue with Improved Lipid. – The O-conotoxins MrVIA, MrVIB, and MfVIA inhibit the voltage-gated sodium channel Na V 1.8, a well described target for the treatment of pain; however, little is known about the residues or structural elements that define this activity. In this study, we determined the three-dimensional structure of MfVIA, examined its membrane binding properties, performed alanine-scanning mutagenesis, and.
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Prevalence and Predictors of Early Cardiovascular Events. – ECG was normal in 198 (81.5%) patients. We reported repolarization abnormalities in 19 (7.8%) patients, conduction anomalies in 14 (5.8%), arrhythmia in 9 (3.7%) and LVH in 3 (1.3%). Echocardiography (n = 238) determined a mean left ventricular ejection fraction (LVEF) of 62.3% 8.3% and identified LVH in 120 (50.4%) patients.
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Prevalence and Predictors of Early Cardiovascular Events. – Cardiovascular disease remains the leading cause of mortality after renal transplantation. Overall, 47% of deaths without kidney failure in the first month post-transplantation are related to cardiovascular disease[1,2,3,4].