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Inhibition of the ERK1/2-mTORC1 axis ameliorates. – Transforming growth factor- (TGF-) plays crucial roles in the development of focal segmental glomerulosclerosis (FSGS), but key molecular pathways remain unknown. Here, we identified the regulation of mammalian target of rapamycin complex1 (mTORC1) by TGF- via extracellular signal-regulated kinase-1/2 (ERK1/2) in the adriamycin (ADR)-induced murine model of focal.
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